Offre de Thèse à l’Université de Strasbourg, IGBMC

lundi 17 septembre 2018
popularité : 7%

Une offre de thèse est disponible dans le groupe de RMN des biomolécules à l’Institut de Génétique et de Biologie Moléculaire et Cellulaire ( IGBMC) pour un travail sur le RMN du Fluor.

Description ci-dessous :

The Group of biomolecular NMR of IGBMC is looking for a PhD candidate to work on Fluorine NMR

Project description :

Fluorine NMR provides a sensitive probe to study molecular interactions in complex environments. In this project, we aim at developing novel spectroscopic tools for the detection and characterisation of various fluorinated compounds such as perfluorinated peptides or proteins. This project emerged from a collaboration between research operating at the interface between chemistry, biology and NMR spectroscopy. The developed tools will find applications in the detection/characterisation of persistent organic pollutants, the study of small organic compounds interactions with large macromolecular complexes or the study of Intrinsically Disordered Proteins.

Qualification :

The candidate must hold a Master’s degree in Chemistry, Biochemistry or Biophysics. A very good knowledge of physical chemistry is required and a previous experience in NMR spectroscopy is a plus. As this project involves international collaborations, a good practice of English reading and writing is expected.

Facilities :

The NMR group has full access to a 600 MHz equipped with a QCI-F cryoprobe as well as a 700 MHz. The group is equipped with state-of-the-art equipments for protein production and biophysical characterisation. The collaborating group at ISIS headed by Vladimir Torbeev masters a wide range of technologies in peptide and protein chemistry. The project is funded both by the ANR and the CASC4DE company.

Contacts :

- Pr Bruno Kieffer
- Dr Vladimir Torbeev

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