Offre de PostDoc au CEISAM, Nantes

vendredi 15 février 2019
par Olivier Girard
popularité : 9%

A post-doc position is available in the NMR group of the CEISAM laboratory, University of Nantes, France.

The postdoctoral researcher will join an ERC-funded project, led by Patrick Giraudeau, on the development of dissolution dynamic polarization for analytical chemistry. The project aims at bringing the reproducibility of dissolution DNP to the level that will unlock an array of applications in metabolomics and other “omics” sciences. This requires working at the interface between hardware development, NMR spectroscopy and analytical chemistry.

The postdoctoral researcher will be in charge of harnessing -on a variety of complex biological samples (model mixtures, extracts, biofluids)- the potential of a new dissolution DNP system that will be installed in CEISAM during the summer 2019. In particular, the postdoctoral researcher will :

- characterize the performance of the new d-DNP setting, and develop solutions to improve its reproducibility or to correct the effect of irreproducibility on the NMR signal ;

- evaluate the performance of the experimental setting on biological samples of increasing complexity ;

- apply the optimized experiments to a variety of “omics” research questions.

Research will involve close collaboration with the group of Prof. Sami Jannin (Université Claude Bernard Lyon 1, France) and with several French teams in metabolomics, as well as numerous interactions with Bruker Biospin.

Applicants should hold a Ph.D. in chemistry or physics, and have a demonstrated track record in magnetic resonance instrumentation. Experience in DNP is desirable but not mandatory. Applicants should also show interest for applications to analytical chemistry. Good communication skills and a propensity for teamwork are also essential.

The NMR group of the CEISAM lab works on methods developments in solution-state NMR and their application to the analysis of mixtures. It is equipped with state-of-the-art NMR spectrometers, in the 400 to 700 MHz range. CEISAM is the molecular chemistry lab of the Université de Nantes and is a joint CNRS research unit, where research includes physical, theoretical and analytical chemistry, organic synthesis and catalysis, and chemical biology. The lab is located in the vibrant city of Nantes, close to the beautiful Atlantic coast of South Brittany.

The position is open from October 1st 2019. The net monthly salary will be between 2000 and 2300 €, depending on experience. The position is initially for 1 year but can be extended to 2 years.

Applications must be sent to patrick.giraudeau@univ-nantes.fr. Please include a cover letter, a CV, and 2 reference letters. Applications will be considered until the position is filled.

Recent publications :

J.-N. Dumez, J. Milani, B. Vuichoud, A. Bornet, J. Lalande-Martin, I. Tea, M. Yon, M. Maucourt, C. Deborde, A. Moing, L. Frydman, G. Bodenhausen, S. Jannin, P. Giraudeau, Hyperpolarized NMR of plant and cancer cell extracts at natural abundance, Analyst, 140, 5860-5863, (2015)

A. Bornet, M. Maucourt, C. Deborde, D. Jacob, J. Milani, B. Vuichoud, X. Ji, J.-N. Dumez, A. Moing, G. Bodenhausen, S. Jannin, P. Giraudeau, Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics, Anal. Chem., 88, 6179–6183, (2016)

B. Plainchont, P. Berruyer, J.-N. Dumez, S. Jannin, P. Giraudeau, Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry, Analytical Chemistry, 90, 3639-3650, (2018)


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